Borcard, FrançoiseStaedler, DavideComas, HoracioKrauss Juillerat, FranziskaSturzenegger, Philip N.Heuberger, RomanGonzenbach, Urs T.Juillerat-Jeanneret, LucienneGerber-Lemaire, Sandrine2012-10-042012-10-04201210.1021/jm301092rhttps://infoscience.epfl.ch/handle/20.500.14299/85938WOS:000309153500005To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized. The binding of this ligand to alumina-based, hydroxyapatite-based, and calcium phosphate-based bioceramics was demonstrated. The conjugation of this ligand to the bioceramics induced a decrease in the nonselective and integrin-selective binding of human serum proteins, whereas the binding and adhesion of human endothelial cells was enhanced, dependent on the particular bioceramics.text::journal::journal article::research article