Georgiadis, Markos-OrestisKourbeli, VioletaIoannidou, VayaKarakitsios, EvangelosPapanastasiou, IoannisTsotinis, AndrewKomiotis, DimitriVocat, AnthonyCole, Stewart T.Taylor, Martin C.Kelly, John M.2019-06-182019-06-182019-06-182019-06-0110.1016/j.bmcl.2019.04.010https://infoscience.epfl.ch/handle/20.500.14299/157927WOS:000465546100004In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.Chemistry, MedicinalChemistry, OrganicPharmacology & PharmacyChemistrydiphenoxyadamantanesubstituted piperazineaminoalkane side chaintrypanocidal activityantimycobacterial activitysolid pharmaceutical formulationsvitro controlled-releaseadamantane aminoethersresistanceepoxidesdrugstext::journal::journal article::research article