Wang, DaquanHou, ChenMeng, LingjieLong, JiangangJing, JiangeDang, DongfengFei, ZhaofuDyson, Paul J.2017-05-012017-05-012017-05-01201710.1039/c6tb02755ehttps://infoscience.epfl.ch/handle/20.500.14299/136715WOS:000395919000005Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimo dal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and photothermal therapy for localized cancer treatment. The agent was constructed layer-by-layer from polypyrrole and gold nanoparticles on multi-walled carbon nanotubes. The gold surface was modified with tumor targeting folic acid terminated PEGylated chains, which also provide water-dispersibility, biocompatibility and should extend the half-life in blood. The material has a high loading/unloading capacity for the cytotoxic agent doxorubicin. Release of the doxorubicin, combined with the photothermal properties of the material that induces localized hyperthermia, leads to efficient cancer cell death.text::journal::journal article::research article