Ziegler, LorricZenke, FriedemannKastner, David BGerstner, Wulfram2015-01-232015-01-232015-01-23201510.1523/JNEUROSCI.3989-14.2015https://infoscience.epfl.ch/handle/20.500.14299/110490WOS:00034941170004125609644Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.synaptic plasticitycomputational neurosciencesynapse modelingconsolidationsynaptic tagging and capturetext::journal::journal article::research article