Aboura, WassilaBatchelor, Lucinda K.Garci, AmineDyson, Paul J.Therrien, Bruno2020-03-032020-03-032020-03-032020-02-0110.1016/j.ica.2019.119265https://infoscience.epfl.ch/handle/20.500.14299/166750WOS:000504763300016Neutral piano-stool complexes of the general formula [(eta(5)-C5Me5)Rh(L-OR)] (R = Me, 1; R = Et, 2; R = Pe(i), 3) have been prepared in alcohols (methanol, 1; ethanol, 2; isopropanol, 3) from the Schiff-base 5-methyl-4-{(pyridin-2-ylmethylene)amino}-4H-1,2,4-triazole-3-thiol (L-H) and the dinuclear precursor [(eta(5)-C5Me5) RhCl2](2). Concomitant with the coordination of the Schiff-base ligand, an alkoxilation occurs on the imine carbon atom of the ligand, thus forming the corresponding L-OR compounds. In these complexes, the L-OR ligand is N,N,S-coordinated, introducing chirality at the metal center. The antiproliferative activity of the piano-stool complexes 1-3 was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing no significant activity in vitro (IC50 > 200 mu M), except for the ethanolate derivative 2, which shows an IC50 of 21 mu M on the ovarian cancer cell line A2780.Chemistry, Inorganic & NuclearChemistrypiano-stool complexesnucleophilic additionschiff-base ligandrhodium complexesbio-organometallic chemistryruthenium(ii) arene complexeshalf-sandwich rutheniumschiff-base ligandin-vitroanticancer activityhuman ovariannns ligandsphase-icoordinationmononucleartext::journal::journal article::research article