Brioche, JulienCourant, ThibautAlcaraz, LilianStocks, MichaelFurber, MarkZhu, JiepingMasson, Géraldine2014-06-082014-06-082014-06-08201410.1002/adsc.201400093https://infoscience.epfl.ch/handle/20.500.14299/104073WOS:000337584200006A highly stereoselective three-component Povarov reaction, catalyzed by (R)- and (S)-BINOL hydrogen phosphate, was achieved for the first time with aminopyrroles and aminopyrazoles as 2-azadiene precursors. A variety of aldehydes, enecarbamates, amino-substituted azines participated in the reaction to afford the tetrahydropyrrolopyridines and tetrahydropyrazolopyridines in good yields with excellent diatereo- and enantioselectivities. A stereochemical model is proposed to account for the observed absolute stereochemistry.asymmetric synthesisaza-Diels–Alder reactionchiral phosphoric acidorganocatalysisPovarov reactiontext::journal::journal article::research article