Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

Gonchar, Maria R.Matnurov, Egor M.Burdina, Tatiana A.Zava, OliverRidel, TinaMilaeva, Elena R.Dyson, Paul JosephNazarov, Alexey A.2020-07-092020-07-092020-07-092020-05-0510.1016/j.jorganchem.2020.121312https://infoscience.epfl.ch/handle/20.500.14299/169953New water-soluble 3,5,6-bicyclophosphite ligands based on glucose modified with uracil, 5-fluorouracil or thymine are reported. The phosphite ligands were subsequently reacted with bis[dichlorido(η6-p-cymene)ruthenium(II)] and trirutheniumdodecacarbonyl to afford monoruthenium analogues of RAPTA-C and triruthenium clusters with 1–3 phosphite ligands, respectively. The influence of ligands on the stability of the compounds and the antiproliferative activity of the compounds was investigated.Ruthenium(II)-arene compoundsTriruthenium-carbonyl clustersAntiprolifirative activityWater-soluble phopsphitesRuthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activitytext::journal::journal article::research article