Renfrew, Anna K.Egger, Alexander E.Scopelliti, RosarioHartinger, Christian G.Dyson, Paul J.2010-12-142010-12-142010-12-14201010.1016/j.crci.2010.03.014https://infoscience.epfl.ch/handle/20.500.14299/62116WOS:000282899600028Metal complexes bearing phosphine ligands are attracting increasing attention for their applications in medicinal chem. In particular, organometallic ruthenium-phosphine complexes have been found to exhibit promising antitumor activity. The synthesis, anticancer activity and reactivity of a novel bis-phosphine complex, [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]Cl (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1.]decane), is presented. The complex appears to exhibit its anticancer effect via a different mechanism to other ruthenium-arene pta complexes with labile co-ligands.Cancer chemotherapyRu-arene complexesBis-phosphineDNA bindingProtein bindingMass spectrometrySynthesisTransition-Metal-ComplexesCoordinated Gold CompoundFlash-Quench TechniqueIn-VitroAnticancer ActivityRuthenium ComplexesAntitumor-ActivityDna-BindingPta ComplexesDrugstext::journal::journal article::research article