Dubey, Lalit KumarLebon, LucMosconi, IlariaYang, Chen-YingScandella, ElkeLudewig, BurkhardLuther, Sanjiv AHarris, Nicola L2016-07-142016-07-142016-07-14201610.1016/j.celrep.2016.04.023https://infoscience.epfl.ch/handle/20.500.14299/127168WOS:000376165300016Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted to the postnatal period, we observed that the draining mesenteric lymph nodes (mLN) of helminth-infected mice form an extensive number of new, centrally located, B cell follicles in response to IL-4Rα-dependent inflammation. IL-4Rα signaling promoted LTα1β2 (lymphotoxin) expression by B cells, which then interacted with CCL19 positive stromal cells to promote lymphoid enlargement and the formation of germinal center containing B cell follicles. Importantly, de novo follicle formation functioned to promote both total and parasite-specific antibody production. These data reveal a role for type 2 inflammation in promoting stromal cell remodeling and de novo follicle formation by promoting B cell-stromal cell crosstalk.text::journal::journal article::research article