Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Montay-Gruel, PierrePetersson, KristofferJaccard, MaudBoivin, GaelGermond, Jean-FrancoisPetit, BenoitDoenlen, RaphaelFavaudon, VincentBochud, FrancoisBailat, ClaudeBourhis, JeanVozenin, Marie-Catherine2017-11-082017-11-082017-11-08201710.1016/j.radonc.2017.05.003https://infoscience.epfl.ch/handle/20.500.14299/142068WOS:000413383700004This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory. (C) 2017 Elsevier B.V. All rights reserved.Flash-RTWhole brain irradiationCognition's preservationIrradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/stext::conference output::conference proceedings::conference paper