Yang, LixinLashuel, Hilal2025-02-032025-02-032025-02-032024https://infoscience.epfl.ch/handle/20.500.14299/246417The invention relates to TDP-43 protein mutants and uses thereof. The invention further relates to methods for the preparation of TDP-43 protein mutants aggregates, including fibrils and uses thereof. The invention further relates to use the TDP-43 protein mutants for the identification and screening of modulators of TDP-43 protein aggregation and related methods.patentWO202422361586226756