A formal total synthesis of deoxybouvardin

Bigot, AntonyBeugelmans, ReneZhu, Jieping2010-11-252010-11-252010-11-25199710.1016/S0040-4020(97)00706-0https://infoscience.epfl.ch/handle/20.500.14299/58552A synthesis of L,L-N,N-dimethylcycloisodityrosine (I) based on an intramol. SNAr reaction is reported. A possible explanation was proposed to account for the facile epimerization encountered in the cycloetherification of dipeptide L,L-II and a soln. to this problem led to a formal total synthesis of deoxybouvardin. [on SciFinder (R)]deoxybouvardin formal total synthesis; intramol nucleophilic arom substitution cycloisodityrosine prepnA formal total synthesis of deoxybouvardintext::journal::journal article::research article