Pioletti, Dominique P.2010-01-192010-01-192010-01-19201010.1080/10255841003630660https://infoscience.epfl.ch/handle/20.500.14299/45583WOS:000285145800022Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach, so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesized and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects in bone tissue engineering: the former could be related to osteoconduction, while the later may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets, but also incorporating some mechanotransduction principles.bone scaffoldload-bearing applicationbiomechanicsmechanotransductiontissue engineeringMesenchymal Stem-CellsFinite-ElementOsteogenic DifferentiationBiophysical PrinciplesMechanical-PropertiesTrabecular BoneFluid-FlowIn-VitroScaffoldsRegenerationtext::journal::journal article::research article