Chen, JinchunChen, XiaochuanWillot, MatthieuZhu, Jieping2010-11-252010-11-252010-11-25200610.1002/anie.200603179https://infoscience.epfl.ch/handle/20.500.14299/58455The limited availability of bioactive natural products for pharmaceutical studies and drug development is a problem that can be solved, in principle, by total synthesis. The potent antitumor marine natural products ecteinascidin 597 (I; R = Me) and ecteinascidin 583 (I; R = H) have now been synthesized from readily accessible starting materials in a highly convergent and stereoselective fashion (see scheme). [on SciFinder (R)]Absolute configuration; Stereoselective synthesis (asym. total syntheses of ecteinascidins 597 and 583); Synthons (chiral; asym. total syntheses of ecteinascidins 597 and 583); Alkaloids Role: SPN (Synthetic preparation)PREP (Preparation) (marine; asym. total syntheses of ecteinascidins 597 and 583)asym synthesis alkaloid ecteinascidin 597 583text::journal::journal article::research article