Elamparuthi, ElangovanFellay, CindyNeuburger, MarkusGademann, Karl2012-05-182012-05-182012-05-18201210.1002/anie.201200515https://infoscience.epfl.ch/handle/20.500.14299/80597WOS:000303001000012The tricyclic diterpene cyrneine A featuring a hexatrienal unit was prepared synthetically for the first time by a Heck reaction, a carbene ring expansion, and a reductive carbonylation. The structure of the natural product was assigned by X‐ray crystal analysis of a synthetic sample.cross-couplingnatural productsneurochemistrystereoselective synthesistotal synthesisRing Enlargement ReactionAsymmetric-SynthesisTricyclic CoreCyathin DiterpenoidsHeck ReactionIntermediateCyclizationtext::journal::journal article::research article