Govender, P.Renfrew, A. K.Clavel, C. M.Dyson, P. J.Therrien, B.Smith, G. S.2011-03-092011-03-092011-03-09201110.1039/c0dt00761ghttps://infoscience.epfl.ch/handle/20.500.14299/65223WOS:000286390300023Chelating neutral (N,O) and cationic (N,N) first-and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N, N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono-and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.Ruthenium ComplexesAnticancer ActivityMolecular-StructureMetal-ComplexesIn-VitroAntitumor-ActivityCatalytic-ActivityRuthenium(Ii)-Arene ComplexesPreclinical DevelopmentNickel-Catalyststext::journal::journal article::research article