Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function

Hitomi, YukiCirulli, Elizabeth T.Fellay, JacquesMcHutchison, John G.Thompson, Alexander J.Gumbs, Curtis E.Shianna, Kevin V.Urban, Thomas J.Goldstein, David B.2011-04-112011-04-112011-04-11201110.1053/j.gastro.2010.12.038https://infoscience.epfl.ch/handle/20.500.14299/66256Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). However, the biologic mechanism by which this occurs is unknown.Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase functiontext::journal::journal article::research article