Dagousset, GuillaumeDrouet, FleurMasson, GeraldineZhu, Jieping2010-11-252010-11-252010-11-25200910.1021/ol9023985https://infoscience.epfl.ch/handle/20.500.14299/58407Reaction of aldehydes, anilines, and enecarbamates in dichloromethane in the presence of EtOH and a catalytic amt. of chiral phosphoric acid I afforded the Mannich adducts which were in situ reduced to anti-1,2-disubstituted 1,3-diamines II in excellent diastereoselectivity and enantioselectivity. [on SciFinder (R)]Amines Role: RCT (Reactant)RACT (Reactant or reagent) (aryl; prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates); Amines Role: SPN (Synthetic preparation)PREP (Preparation) (diaminesanti; prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates); Carbamates Role: RCT (Reactant)RACT (Reactant or reagent) (ene; prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates); Mannich reaction catalysts; Multicomponent reaction; Stereoselective synthesis (prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates); Aldehydes Role: RCT (Reactant)RACT (Reactant or reagent) (prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates); Mannich reaction (stereoselective; prepn. of anti-diamines via chiral Bronsted acid-catalyzed multicomponent Mannich reaction of aldehydesanilinesand enecarbamates)aldehyde aniline enecarbamate Bronsted acid catalyst multicomponent Mannich reaction; anti disubstituted diamine stereoselective prepntext::journal::journal article::research article