Evans, James E.Hetherington, CrispinKirkland, AngusChang, Lan-YunStahlberg, HenningBrowning, Nigel2020-02-132020-02-132020-02-132008-11-0110.1016/j.ultramic.2008.06.004https://infoscience.epfl.ch/handle/20.500.14299/165444Spherical aberration (C-s) correction in the transmission electron microscope has enabled sub-angstrom resolution imaging of inorganic materials. To achieve similar resolution for radiation-sensitive organic materials requires the microscope to be operated under hybrid conditions: low electron dose illumination of the specimen at liquid nitrogen temperature and low defocus values. Initial images from standard inorganic and organic test specimens have indicated that under these conditions C-s-correction can provide a significant improvement in resolution (to less than 0.16 nm) for direct imaging of organic samples. (C) 2008 Published by Elsevier B.V.Low-dose aberration corrected cryo-electron microscopy of organic specimenstext::journal::journal article::research article