Groessl, MichaelHartinger, Christian G.Dyson, Paul J.Keppler, Bernhard K.2008-07-292008-07-292008-07-29200810.1016/j.jinorgbio.2007.11.018https://infoscience.epfl.ch/handle/20.500.14299/27144WOS:000256239600009Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research. Hydrolysis and DNA binding play an important role for pharmaceutical formulation and for exerting anticancer activity. Herein, for the first time the application of capillary zone electrophoresis-inductively-coupled plasma mass spectrometry (CZE-ICP-MS) for studying the hydrolytic stability and the binding of the ruthenium anticancer drug candidates KP418, KP1019, and RAPTA-C to dGMP is described. RAPTA-C was found to hydrolyze fastest and showed the highest reactivity toward the DNA model compd., whereas KP418 was the most stable compd. in both these respects.text::journal::journal article::research article