Synthesis of a model bicyclic C-O-D-O-E ring of vancomycin by a one-pot, double SNAr based macrocyclization

Beugelmans, ReneBois-Choussy, MicheleVergne, CarolineBouillon, Jean-PhilippeZhu, Jieping2010-11-252010-11-252010-11-25199610.1039/cc9960001029https://infoscience.epfl.ch/handle/20.500.14299/58563Double cyclization of linear pentapeptide I by treatment with CsF in DMF at -5 Deg gives a model bicyclic (C)-O-(D)-O-(E) ring analog of vancomycin in a one step. [on SciFinder (R)]Peptides Role: RCT (Reactant)SPN (Synthetic preparation)PREP (Preparation)RACT (Reactant or reagent) (synthesis of model bicyclic ring of vancomycin by double macrocyclization)vancomycin model bicyclic ring prepn; cyclization substitution nucleophilic tripeptideSynthesis of a model bicyclic C-O-D-O-E ring of vancomycin by a one-pot, double SNAr based macrocyclizationtext::journal::journal article::research article