Enantioselective Rhodium(I)-Catalyzed [3+2] Annulations of Aromatic Ketimines Induced by Directed C?H Activations

Tran, Duc N.Cramer, Nicolai2012-06-122012-06-122012-06-12201110.1002/anie.201105766https://infoscience.epfl.ch/handle/20.500.14299/81630WOS:000297467100008Triple selectivity: Highly substituted indenylamines can be obtained with high enantioselectivity by formal [3+2] additions of aryl ketimines with internal alkynes. These rhodium(I)-catalyzed processes proceed by selective C-H activation of one of the two arene substituents, regioselective carbometalation of the alkyne, and enantioselective addition across the imine. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.alkynesannulationasymmetric catalysisC?H activationrhodiumH Bond ActivationCatalyzed Direct ArylationOrganic-SynthesisCarbon-HydrogenIntermolecular HydroacylationRegioselective SynthesisBenzoic-AcidsAlkynesFunctionalizationCleavageEnantioselective Rhodium(I)-Catalyzed [3+2] Annulations of Aromatic Ketimines Induced by Directed C?H Activationstext::journal::journal article::research article