Harris, NicolaGause, William C.2011-05-102011-05-102011-05-10201110.1016/j.it.2010.11.005https://infoscience.epfl.ch/handle/20.500.14299/67194WOS:000288342100006Similar T helper (Th)2-type immune responses are generated against different helminth parasites, but the mechanisms that initiate Th2 immunity, and the specific immune components that mediate protection against these parasites, can vary greatly. B cells are increasingly recognized as important during the Th2-type immune response to helminths, and B cell activation might be a target for effective vaccine development. Antibody production is a function of B cells during helminth infection and understanding how polyclonal and antigen-specific antibodies contribute should provide important insights into how protective immunity develops. In addition, B cells might also contribute to the host response against helminths through antibody-independent functions including, antigen presentation, as well as regulatory and effector activity. In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites.Larval Strongyloides-StercoralisSchistosoma-Mansoni InfectionGastrointestinal Nematode ParasiteIl-4-Producing T-CellsTrichinella-SpiralisProtective ImmunityIn-VivoMonoclonal-AntibodyPassive TransferMultiple-Sclerosistext::journal::journal article::review article