Gönczy, Pierre2008-08-312008-08-312008-08-31200810.1038/nrm2388https://infoscience.epfl.ch/handle/20.500.14299/27669WOS:00025526530001112481Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammalsAnimalsCaenorhabditis elegans/cytologyCell Cycle Proteins/metabolismCell Division/physiologyCell PolarityCentrosome/metabolismDrosophila Proteins/genetics/metabolismDrosophila melanogaster/cytologyEmbryoNonmammalian/cytology/physiologyGTP-Binding Protein alpha Subunits/metabolismHelminth Proteins/genetics/metabolismJuvenile Hormones/genetics/metabolismMitotic Spindle Apparatus/metabolism/ultrastructureProtein FoldingReceptorsNotch/genetics/metabolismSignal Transduction/physiologyUbiquitin-Protein Ligases/genetics/metabolismtext::journal::journal article::review article