Gerber-Lemaire, SandrineCarmona, Ana T.Meilert, Kai T.Vogel, Pierre2006-02-162006-02-16200610.1002/ejoc.200500670https://infoscience.epfl.ch/handle/20.500.14299/224105WOS:0002354040000088114A total asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397 was developed through the stereoselective functionalization of (1R,1’S,6S,6’R)-3,3’-methylenebis(cyclohept-3-ene-1,6-diol). The pathway generates a large variety of stereoisomeric intermediates and thus can be applied to the preparation of analogues of the natural antibiotic.long-chain polyolpolyene macrolide antibioticstereoselective functionalizationSharpless asymmetric dihydroxylationAsymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397text::journal::journal article::research article