Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer's disease

Fraering, PatrickDimitrov, Mitko2014-04-222014-04-22201410.5075/epfl-thesis-6071https://infoscience.epfl.ch/handle/20.500.14299/102917urn:nbn:ch:bel-epfl-thesis6071-5enAlzheimer’s diseaseγ-secretase complexAmyloid precursor proteinFamilial Alzheimer’s mutationsAPP intracellular domainrecombinant protein expressionγ-secretase modulatorsγ-secretase inhibitorsNotch signalingmass spectrometryPharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer's diseasethesis::doctoral thesis