Singh, P.Benjak, A.Carat, S.Kai, M.Busso, P.Avanzi, C.Paniz-Mondolfi, A.Peter, C.Harshman, K.Rougemont, J.Matsuoka, M.Cole, S. T.2015-02-202015-02-202015-02-20201410.1111/1469-0691.12609https://infoscience.epfl.ch/handle/20.500.14299/111654WOS:000345825900006Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M.leprae.Leprosymolecular epidemiologyMycobacterium lepraerifampicin-resistancesingle nucleotide polymorphismtext::journal::journal article::research article