Houtkooper, RichardusAuwerx, Johan2012-10-212012-10-212012-10-21201210.1083/jcb.201207019https://infoscience.epfl.ch/handle/20.500.14299/86227WOS:00030998240000423071150NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD(+) signaling pathway are being translated to the clinic.text::journal::journal article::review article