000099263 001__ 99263
000099263 005__ 20180317093950.0
000099263 022__ $$a0033-3158
000099263 037__ $$aARTICLE
000099263 245__ $$aAdministration of leu-enkephalin impairs the acquisition of preference for ethanol
000099263 260__ $$c1990
000099263 269__ $$a1990
000099263 336__ $$aJournal Articles
000099263 500__ $$aAuthor address: Department of Psychobiology, Cajal Institute, Madrid, Spain.
000099263 520__ $$aThe effects of subcutaneous administration of leu-enkephalin (LEU-E) (10, 100 and 300 micrograms/kg) and LEU-E (100 micrograms/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditions, rats develop ethanol preference through forced ethanol drinking (conditioning session). Preconditioning administration of LEU-E induced a reduction of later ethanol preference. Post-conditioning administration of LEU-E (10 and 100 micrograms/kg) also attenuated the development of ethanol preference. NX antagonized the effects of LEU-E on ethanol preference and fluid consumption in the two experimental procedures used, indicating an involvement of opioid receptors in the LEU-E-induced impairment of the acquisition of ethanol preference.
000099263 6531_ $$aAlcohol Drinking/ drug effects
000099263 6531_ $$aAnimals
000099263 6531_ $$aConditioning
000099263 6531_ $$aOperant/ drug effects
000099263 6531_ $$aEnkephalin
000099263 6531_ $$aLeucine/ pharmacology
000099263 6531_ $$aEthanol/ pharmacology
000099263 6531_ $$aMale
000099263 6531_ $$aNaloxone/pharmacology
000099263 6531_ $$aRats
000099263 6531_ $$aRats
000099263 6531_ $$aInbred Strains
000099263 700__ $$0243016$$aSandi, Carmen$$g160090
000099263 700__ $$aBorrell, José
000099263 700__ $$aGuaza, Carmen
000099263 773__ $$j100$$k3$$q350-4$$tPsychopharmacology (Berl)
000099263 909CO $$ooai:infoscience.tind.io:99263$$particle$$pSV
000099263 909C0 $$0252121$$pLGC$$xU10913
000099263 917Z8 $$x192880
000099263 937__ $$aLGC-ARTICLE-1990-004
000099263 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000099263 980__ $$aARTICLE