Effects of the kappa opioid receptor antagonist MR-2266-BS on the acquisition of ethanol preference
Using a paradigm by which rats forced to drink a weak ethanol solution (2.5% w/v) (conditioning session) develop ethanol preference in consecutive retention testing days, the effects of the administration of the kappa opioid antagonist MR-2266-BS, prior to or after the forced ethanol session, were studied. Pre-conditioning subcutaneous (s.c.) administration of 1 mg/kg of MR-2266-BS induced a decrease in subsequent ethanol consumption without significantly modifying the acquisition of ethanol preference. Post-conditioning administration of MR-2266-BS (0.1, 1, 5 or 10 mg/kg) induced both a dose-dependent reduction in ethanol consumption and in preference throughout the three following days. The results of the present study provide further support of the involvement of kappa-type opioids on drinking behavior, and suggest that kappa receptors may be involved in the consumption and development of preference to ethanol.
Keywords: Alcohol Drinking/ drug effects ; Animals ; Benzomorphans/administration & dosage/ pharmacology ; Conditioning (Psychology) ; Drinking Behavior/ drug effects ; Male ; Morphinans/ pharmacology ; Rats ; Rats ; Inbred Strains ; Receptors ; Opioid/ antagonists & inhibitors ; Receptors ; Opioid ; kappa ; Regression Analysis ; Sucrose/administration & dosage
Author address: Cajal Institute, Department of Psychobiology, C.S.I.C., Madrid, Spain.
Record created on 2007-01-18, modified on 2016-08-08