000098627 001__ 98627
000098627 005__ 20190316233909.0
000098627 0247_ $$2doi$$a10.1002/(SICI)1097-0290(19970420)54:2<91::AID-BIT1>3.0.CO;2-Q
000098627 037__ $$aARTICLE
000098627 245__ $$aEffects of spatiotemporal variations on metabolic control: approximate analysis using (log)linear kinetic models
000098627 269__ $$a1997
000098627 260__ $$c1997
000098627 336__ $$aJournal Articles
000098627 500__ $$a16-8 FIELD Section Title:Fermentation and Bioindustrial Chemistry
000098627 500__ $$aInstitute of Biotechnology, ETH-Zurich,Zurich,Switz. FIELD URL:
000098627 500__ $$awritten in English.
000098627 520__ $$aFor many metabolic systems, available exptl. data allow description of the system by elasticities and control coeffs. The availability of information of this kind motivated the development of a (log)linear kinetic model of metabolic systems that is completely and explicitly detd. by this information. It is shown here that this model can accurately describe the dynamic responses of metabolic systems that exhibit strong non-linearities. Based on the excellent approxn. provided by the (log)linear model, a method is developed for the estn. of the performance of metabolic systems subject to spatiotemporal variations of the system parameters and the process operating conditions. The method suggests expts. that can quantify the effect of these variations. Study of a model glycolytic pathway illustrates the applicability and the usefulness of this framework. Time-av. flux control coeffs. are shown to vary strongly and not monotonically as the period of the external variations changes. [on SciFinder (R)]
000098627 6531_ $$amodel microorganism metab fermn
000098627 700__ $$0240657$$g174688$$aHatzimanikatis, Vassily
000098627 700__ $$aBailey, James E.
000098627 773__ $$j54$$tBiotechnology and Bioengineering$$k2$$q91-104
000098627 8564_ $$uhttps://infoscience.epfl.ch/record/98627/files/vh-1997-5.pdf$$zn/a$$s278545
000098627 909C0 $$xU11422$$0252131$$pLCSB
000098627 909CO $$ooai:infoscience.tind.io:98627$$qGLOBAL_SET$$pSB$$particle
000098627 937__ $$aLCSB-ARTICLE-1997-003
000098627 970__ $$a0000000044/LCSB
000098627 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000098627 980__ $$aARTICLE