Predicting spike times of a detailed conductance- based neuron model driven by stochastic spike arrival

Reduced models of neuronal activity such as Integrate-and-Fire models allow a description of neuronal dynamics in simple, intuitive terms and are easy to simulate numerically. We present a method to fit an Integrate-and-Fire-type model of neuronal activity, namely a modified version of the Spike Response Model, to a detailed Hodgkin-Huxley-type neuron model driven by stochastic spike arrival. In the Hogkin-Huxley model, spike arrival at the synapse is modeled by a change of synaptic conductance. For such conductance spike input, more than 70% of the postsynaptic action potentials can be predicted with the correct timing by the Integrate-and-Fire-type model. The modified Spike Response Model is based upon a linearized theory of conductance-driven Integrate-and-Fire neuron.


Published in:
J. Physiol. Paris, 98, 4-6, 442-451
Year:
2004
Publisher:
Elsevier
ISSN:
0928-4257
Keywords:
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 Record created 2006-12-12, last modified 2018-01-27

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