Notch regulation of lymphocyte development and function
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14985712
Keywords: Animals ; B-Lymphocytes/*immunology ; Cell Lineage ; Hematopoiesis ; Hematopoietic Stem Cells/physiology ; Humans ; Leukemia ; T-Cell/immunology ; *Lymphopoiesis ; Membrane Proteins/*physiology ; Mice ; Receptors ; Notch ; Research Support ; Non-U.S. Gov't ; Signal Transduction ; T-Lymphocytes/*immunology ; Thymus Gland/cytology/immunology
The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. email@example.com
Record created on 2006-12-05, modified on 2016-08-08