Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14718516
Keywords: Animals ; B-Lymphocytes/cytology/immunology ; Cell Differentiation ; Cell Division ; Chimera ; Cytoskeletal Proteins/deficiency/genetics/*physiology ; Female ; Hematopoiesis/genetics/*physiology ; Integrases/genetics ; Lymphopoiesis/genetics/*physiology ; Mice ; Mice ; Inbred C57BL ; Mice ; Knockout ; Phenotype ; Proto-Oncogene Proteins/genetics/physiology ; Research Support ; Non-U.S. Gov't ; Signal Transduction ; T-Lymphocytes/cytology/immunology ; Trans-Activators/deficiency/genetics/*physiology ; Wnt Proteins ; beta Catenin
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
Record created on 2006-12-05, modified on 2016-08-08