Notch1 and T-cell development: insights from conditional knockout mice
2001
Abstract
Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.
Details
Title
Notch1 and T-cell development: insights from conditional knockout mice
Author(s)
MacDonald, H. R. ; Wilson, A. ; Radtke, F.
Published in
Trends in Immunology
Volume
22
Issue
3
Pages
155-160
Date
2001
ISSN
1471-4906
Keywords
Animals; B-Lymphocytes/cytology/immunology; CD4-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/cytology; Cell Differentiation; Cell Lineage; Membrane Proteins/genetics/*physiology; Mice; Mice; Knockout; Receptor; Notch1; Receptors; Antigen; T-Cell; alpha-beta; Receptors; Antigen; T-Cell; gamma-delta; *Receptors; Cell Surface; Signal Transduction/physiology; T-Lymphocytes/*cytology/immunology; *Transcription Factors
Note
The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066, Epalinges, Switzerland. hughrobson.macdonald@isrec.unil.ch
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Laboratories
UPRAD
Record Appears in
Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPRAD - Prof. Radtke Group
Peer-reviewed publications
Work produced at EPFL
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Published
Peer-reviewed publications
Work produced at EPFL
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Published
Record creation date
2006-12-05