T cell fate specification and alphabeta/gammadelta lineage commitment

The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.


Published in:
Curr Opin Immunol, 13, 2, 219-24
Year:
2001
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Note:
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH-1066, Epalinges, Switzerland. HughRobson.MacDonald@isrec.unil.ch
0952-7915 (Print)
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 Record created 2006-12-05, last modified 2018-12-03

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