Abstract
Recent studies have begun to unravel some of the molecular pathways that appear to control the processes of T cell determination in the earliest thymocyte precursors. In addition, the analyses of mouse mutants with an entirely alymphoid thymus have shed light on the developmental relationship of pro-T cells and thymic dendritic cells, revealing that development of thymocytes and thymic dendritic cells can be dissociated.
Details
Title
To be or not to be a pro-T?
Author(s)
Di Santo, J. P. ; Radtke, F. ; Rodewald, H. R.
Published in
Current Opinion in Immunology
Volume
12
Issue
2
Pages
159-65
Date
2000
ISSN
0952-7915
Keywords
Animals; Cell Differentiation; Cell Lineage; Cytokines/physiology; Dendritic Cells/cytology; *Gene Expression Regulation; Developmental; Helix-Loop-Helix Motifs; *Hematopoiesis/genetics; Hematopoietic Cell Growth Factors/physiology; Hematopoietic Stem Cells/*cytology; Humans; Inhibitor of Differentiation Protein 1; Membrane Proteins/physiology; Mice; Radiation Chimera; Receptors; Cytokine/physiology; Receptors; Notch; *Repressor Proteins; Research Support; Non-U.S. Gov't; Signal Transduction; T-Lymphocyte Subsets/*cytology; Thymus Gland/cytology; Transcription Factors/classification/physiology; Transcription; Genetic
Note
Unite des Cytokines et Developpement Lymphoide, Institut Pasteur, Paris, F-75724, France. disanto@pasteur.fr
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Journal Article
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Other identifier(s)
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Laboratories
UPRAD
Record Appears in
Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPRAD - Prof. Radtke Group
Peer-reviewed publications
Work produced at EPFL
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Published
Peer-reviewed publications
Work produced at EPFL
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Published
Record creation date
2006-12-05