Stereoselective total synthesis of (-)-galantinic acid

A concise, practical and stereoselective total synthesis of galantinic acid, constituent of the peptide antibiotic galantin, is reported. The title compound is obtained in six steps via Heathcock-Claisen condensation, Evans reduction and deprotection in 10% overall yield from protected serine. The route described herein thus constitutes the shortest and most efficient procedure for the preparation of the title compound disclosed so far.


Published in:
Synlett, 10, 1580-1582
Year:
2006
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2006-11-22, last modified 2018-03-17

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postprint_SL_2006_1580 - Download fulltextPDF
s-2006-941602 - Download fulltextPDF
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