A biomimetic route to the peptide alkaloid anachelin

A postulated biogenesis forms the basis for a synthetic route to the natural product anachelin H. Key steps include a tellurium-mediated, oxidative aza annulation and a Claisen condensation under mild conditions. Experiments with a model substrate indicate that it is likely that a catechol oxidase-type enzyme is involved in the biosynthesis of the anachelin chromophore.


Published in:
Angewandte Chemie, International Edition, 43, 25, 3327-3329
Year:
2004
Keywords:
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 Record created 2006-11-22, last modified 2018-03-17

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