Synchrotron radiation Imaging of internal structures in live animals
Ionizing radiation has long been used in medicine since the discovery of X-rays. Diagnostic imaging using synchrotron radiation has been under investigation since Rubenstein et al. reported dual-energy iodine-K-edge subtraction coronary angiography. Recently, computed tomography (CT) and magnetic resonance imaging (MRI) have provided better quality results than conventional radiology, providing important information on human internal structures. However, such techniques are unable to detect fine micron sized structures for the early diagnosis of tumors, vascular diseases and other medical objectives. Third generation synchrotron X-rays are well known for their superiority in coherence and energy tunability with respect to conventional X-rays. Consequently, new contrast mechanisms with a superior spatial resolution are becoming available. Here we present the extremely fine details of five animal internal structures using unmonochromatized synchrotron X-rays (white beam) and a simple detector system. Natural movements of the internal organs are also shown. The results indicate that this imaging technique can be applied to investigating microstructures and evaluating the function of the internal organs. Furthermore, this imaging system may be applied to humans as the next tool beyond CT and MRI.
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Keywords: synchrotron radiation ; white beam ; imaging technique ; phase contrast ; internal organ ; X-RAY CT ; COMPUTED-TOMOGRAPHY ; CORONARY ANGIOGRAPHY ; MAMMOGRAPHY ; MODEL ; MICROANGIOGRAPHY ; MICROTOMOGRAPHY ; ANGIOGENESIS ; SPECIMEN ; GROWTH
Acad Sinica, Med Res Ctr, Taipei 11529, Taiwan. Acad Sinica, Inst Phys, Taipei 11529, Taiwan. Pohang Univ Sci & Technol, Dept Mat Sci, Pohang, South Korea. Yonsei Univ, Coll Med, Dept Radiol, Seoul 120749, South Korea. Yonsei Univ, Coll Dent, Dept Periodontol, Seoul 120749, South Korea. Ecole Polytech Fed Lausanne, IPA, CH-1015 Lausanne, Switzerland. Lee, KH, Yonsei Med Res Ctr, CPO Box 8044, Seoul 120752, South Korea.
ISI Document Delivery No.: 527NM
Record created on 2006-10-03, modified on 2016-08-08