Frontiers of X-ray spectromicroscopy in biology and medicine: Gadolinium in brain cancer

We present the first feasibility test of spectromicroscopy on the microlocalization of gadolinium in brain cancer tissue. A gadolinium compound was injected to the patients before the brain tumor was extracted with surgery, and we looked for Gd in the tumor tissue. The goal of the experiment was to understand if Gd Neutron Capture Therapy (GdNCT) is viable for clinical tests, i.e. if there is enough Gd, and it is localized near the nuclei of tumor cells. The experiments were performed using the MEPHISTO X-ray PhotoElectron Emission Microscope (X-PEEM) at the Wisconsin Synchrotron Radiation Center. The present results demonstrate the feasibility of the experiment, and suggest how to improve the sample preparation and data acquisition to achieve the goal.


Published in:
X-Ray and Inner-Shell Processes, 506, 577-584
Year:
2000
Publisher:
Aip Press
ISSN:
0094-243X
ISBN:
1-56396-713-8
Keywords:
Note:
Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.De Stasio, G, Univ Wisconsin, Dept Phys, 1150 Univ Ave, Madison, WI 53706 USA.
ISI Document Delivery No.: BP76A
Cited Reference Count: 12
Article
18th International Conference on X-ray and Inner-Shell Processes
AUG 23-27, 1999
CHICAGO, ILLINOIS
Argonne Natl Lab, Natl Sci Fdn, Int Union Pure & Appl Phys, Roper Scientific
AMERICAN INSTITUTE OF PHYSICS 500 SUNNYSIDE BOULEVARD, WOODBURY, NY 11797-2999 USA
Laboratories:




 Record created 2006-10-03, last modified 2018-03-18


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