Cobalt-doping of Bi2Sr2CaCu2Ox beyond a critical level of 1.5-1.7 at % produces both a large decrease in the superconducting transition critical temperature and all of the classic symptoms of Anderson localization. These include: a negative slope of the ab-plane resistivity vs temperature, no dispersing states near the Fermi level and a decrease of the photoemission signal in the same region.