Journal article

Synchrotron refractive-index microradiography of human liver cancer tissue

Three human liver tissue samples (similar to 5 mm x 40 mm x 20 mm) were excised from a cancer patient's liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the cancer area. Blood vessels with a diameter smaller than 20 pm could be identified. These findings were fully consistent with the histopathological examination of the same area. Microradiographs of the newly formed blood vessels at different angles were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic imaging for clinic diagnosis of liver cancer at the early stage.

    Keywords: synchrotron microradiology ; liver cancer ; histopathology ; CT


    Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. Acad Sinica, Inst Phys, Taipei, Taiwan. Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang, South Korea. Ecole Polytech Fed Lausanne, IPA Ecole, CH-1015 Lausanne, Switzerland. Shanghai CDC, Shanghai 200336, Peoples R China. Zhang, GL, Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.

    ISI Document Delivery No.: 005ZX


    Record created on 2006-10-03, modified on 2017-05-12


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