SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle

The mechanisms governing centrosome duplication remain poorly understood. We identified a gene called sas-4 that is essential for this process in C. elegans. SAS-4 encodes a predicted coiled-coil protein that localizes to a tiny dot in the center of centrosomes throughout the cell cycle. FRAP experiments with GFP-SAS-4 transgenic embryos reveal that SAS-4 is recruited to the centrosome once per cell cycle, at the time of organelle duplication. Additional evidence indicates that SAS-4 is recruited to the daughter centriole or a closely associated structure. These findings identify SAS-4 recruitment as a key step in the centrosome duplication cycle.


Published in:
Dev Cell, 4, 3, 431-9
Year:
2003
Keywords:
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Swiss Institute for Experimental, Cancer Research (ISREC), CH-1066 Epalinges/, Lausanne, Switzerland.
1534-5807 (Print)
Journal Article
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 Record created 2006-08-24, last modified 2018-12-03

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