Mechanisms of nuclear positioning
The mechanisms underlying two types of microtubule-dependent nuclear positioning are discussed. 'MTOC-dependent nuclear positioning' occurs when a nucleus is tightly associated with a microtubule organizing center (MTOC). 'Nuclear tracking along microtubules' is analogous to the motor-driven motility of other organelles and occurs when the nucleus lacks an associated MTOC. These two basic types of microtubule-dependent nuclear positioning may cooperate in many proliferating animal cells to achieve proper nuclear positioning. Microtubule polymerization and dynamics, motor proteins, MAPs and specialized sites such as cortical anchors function to control nuclear movements within cells.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9683624
Keywords: Animals ; Cell Nucleus/*physiology ; Centrosome/physiology ; Dynein ATPase/physiology ; Female ; Humans ; Male ; Microtubules/physiology ; Models ; Biological ; Movement/physiology ; Research Support ; Non-U.S. Gov't ; Saccharomyces cerevisiae/physiology
EMBL, Cell Biology Programme, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. reinsch@EMBL-Heidelberg.de
Record created on 2006-08-24, modified on 2016-08-08