000086095 001__ 86095
000086095 005__ 20180317094859.0
000086095 037__ $$aARTICLE
000086095 245__ $$aHox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group
000086095 260__ $$c1997
000086095 269__ $$a1997
000086095 336__ $$aJournal Articles
000086095 500__ $$aJournal Article
000086095 520__ $$aIt has been previously shown that Hox gene expression in the rhombencephalon is controlled by environmental cues. Thus posterior transposition of anterior rhombomeres to the r7/8 level results in the activation of Hox genes of the four first paralog groups and in homeotic transformations of the neuroepithelial fate according to its position along the anteroposterior axis. We demonstrate here that although the anteroposterior levels of r2 to r6 express Hox genes they do not have inducing activity on more anterior territories. If transposed at the posterior rhombencephalon and trunk level, however, the same anterior regions are able to express Hox gene such as Hoxa-2, a-3 or b-4. We also provide evidence that these signals are transferred by two paths: one vertical, arising from the paraxial mesoderm, and one planar, travelling in the neural epithelium. The competence to express Hox genes extends up to the forebrain and midbrain but expression of Hox genes does not preclude Otx2 expression in these territories and results only in slight changes in their phenotypes. Similarly, rhombomeres transplanted to posterior truncal levels turned out to be able to express posterior genes of the first eight paralog groups to the exclusion of others located downstream in the Hox genes genomic clusters. This suggests that the neural tube is divided into large territories characterized by different Hox gene regulatory features.
000086095 6531_ $$aAnimals
000086095 6531_ $$aBrain Tissue Transplantation
000086095 6531_ $$aCell Differentiation/genetics
000086095 6531_ $$aCentral Nervous System/ embryology/metabolism
000086095 6531_ $$aChick Embryo
000086095 6531_ $$aGene Expression Regulation
000086095 6531_ $$aDevelopmental/ genetics
000086095 6531_ $$aGenes
000086095 6531_ $$aHomeobox
000086095 6531_ $$aHistocytochemistry
000086095 6531_ $$aHomeodomain Proteins/biosynthesis/genetics
000086095 6531_ $$aIn Situ Hybridization
000086095 6531_ $$aRhombencephalon/ embryology/metabolism/transplantation
000086095 6531_ $$aSpinal Cord/embryology
000086095 700__ $$0240727$$aGrapin-Botton, A.$$g169494
000086095 700__ $$aBonnin, M. A.
000086095 700__ $$aLe Douarin, N. M.
000086095 773__ $$j124$$k4$$q849-59$$tDevelopment
000086095 909CO $$ooai:infoscience.tind.io:86095$$particle
000086095 909C0 $$0252167$$pUPGRA$$xU11258
000086095 937__ $$aUPGRA-ARTICLE-1997-002
000086095 970__ $$a27/UPGRA
000086095 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000086095 980__ $$aARTICLE