Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors
Popowycz, Florence; Gerber-Lemaire, Sandrine; Demange, Raynald; Rodriguez-Garcia, Eliaizar; Carmona Asenjo, Ana Teresa; Robina, Inmaculada; Vogel, Pierre
2001

Abstract

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K-i=7.4 VM) and selective inhibition of alpha -mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.

Details

Title Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors
Author(s) Popowycz, Florence ; Gerber-Lemaire, Sandrine ; Demange, Raynald ; Rodriguez-Garcia, Eliaizar ; Carmona Asenjo, Ana Teresa ; Robina, Inmaculada ; Vogel, Pierre
Published in Bioorganic and Medicinal Chemistry Letters
Volume 11
Issue 18
Pages 2489-2493
Date 2001
Keywords
DOI https://doi.org/10.1016/S0960-894X(01)00477-2
Laboratories LGSA
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LGSA - Laboratory of Glycochemistry and Asymmetric Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2006-06-08

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