Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K-i=7.4 VM) and selective inhibition of alpha -mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.


Published in:
Bioorganic and Medicinal Chemistry Letters, 11, 2489-2493
Year:
2001
Keywords:
Laboratories:




 Record created 2006-06-08, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)