The transfer of cyclodextrins to unusual acceptors in order to synthesize functionalized linear dextrins with the cyclodextrin glycosyltransferase from Klebsiella pneumoniae was investigated. This enzyme catalyzed the transfer of a-cyclodextrin only. The acceptor mol. had to contain D-glucose with the reducing C1 position blocked and the C4 position underivatized. The transfer products may be of interest as defined substrates in enzymol., as modified carbohydrates for dietetic foods, and as carrier systems for drugs.
Title
Production of functionalized dextrins by enzymic transfer of a-cyclodextrin
Published in
Technology of biological processes - safety in biotechnology - applied genetic engineering
Series
DECHEMA Biotechnology Conferences, 1
Pages
161-6
Conference
5th DECHEMA Annual Meeting of Biotechnologists, May 12/13, 1987
Date
1988
Note
CAN 112:117238 16-2 Fermentation and Bioindustrial Chemistry Inst. Chem. Eng.,Swiss Fed. Inst. Technol.,Lausanne,Switz. Journal 0934-3792 written in English. 9030-09-5 (Cyclodextrin-glycosyltransferase) Role: BIOL (Biological study) (from Klebsiella pneumoniae, a-cyclodextrin conversion to linear dextrins with); 57-50-1 Role: BIOL (Biological study) (linear dextrins prepn. from cyclodextrin and, enzymic); 10016-20-3 (a-Cyclodextrin) Role: BIOL (Biological study) (linear dextrins prepn. from, by cyclodextrin glycosyltransferase from Klebsiella pneumonia); 9004-53-9P (Dextrin) Role: PREP (Preparation) (prepn. of, from a-cyclodextrin by glycosyltransferase from Klebsiella pneumoniae)
Record creation date
2006-04-18
