The Bright Future of Stereoselective Synthesis of Coordination Compounds

Transfer of chirality during the build-up of molecules has been applied innumerable times in organic chemistry since the end of the 19th century, when it was introduced in the so-called asymmetric synthesis by E. Fischer. Although analogous reactions were introduced in co-ordination chemistry in its early development, diastereoselective reactions have not been applied in a very systematic way for co-ordination species. The highly versatile co-ordination geometry of metal centres makes the synthesis of a selected stereoisomer in general a formidable task. In the present article an account on new developments in the field is given, focussing on recently synthesized molecules, where natural chiral products are used to create a large number of chiral ligands which predetermine the chirality at metal centres.


Published in:
Journal of the Chemical Society, Dalton Transactions, 3, 219-231
Year:
2000
Laboratories:




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